血尿素在心力衰竭中的预测值:系统性审查和元分析
Siyu Duan1, Yuqi Li1, Ping Yang2
1Second Clinical Medical School, Medical University of Kunming, Kunming, China.
Frontiers in cardiovascular medicine
|August 16, 2023
概括
高血尿酸 (BUN) 水平显著增加心力衰竭 (HF) 患者死亡风险. 较低的BUN与更好的预后有关,突出显示BUN是HF死亡率的关键预测因素.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
背景情况:
- 心力衰竭 (HF) 与高死亡率有关.
- 血尿素 (BUN) 在HF期间在脏血流 perfusion 中起作用.
- 之前关于BUN和HF预后之间的关联的研究已经产生了不一致的结果.
研究的目的:
- 进行全面的元分析,调查BUN在心力衰竭患者的预后价值.
- 为了澄清有关BUN和心力衰竭结果的不一致的发现.
主要方法:
- 在PubMed,Cochrane,Embase和Web of Science中对英语研究进行系统的文献搜索,截至2022年5月.
- 包括19个队列研究,共56003名患者.
- 统计分析 BUN 数据,作为连续和分类变量处理,使用 stata15.0.0.
主要成果:
- 当分类分析时,BUN水平升高与HF患者死亡风险增加2.29倍有关 (RR=2.29,95% CI:1.42-3.70).
- 作为连续变量,BUN的单位增加与死亡风险增加1.02倍相关 (RR=1.02,95% CI:1.01-1.03).
- 在各种子组中观察到统计学意义,包括前性和后性队列,以及欧洲,亚洲和美国人口.
结论:
- 高血尿 (BUN) 是心力衰竭患者全因死亡率的独立预测因子.
- 较低的BUN水平与心力衰竭患者的更好的预后有关.
- BUN 作为心力衰竭管理中的一个有价值的预后标志物.
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