在大鼠系统性炎症期间的呼吸模式变化和心肺呼吸器合的动力学
Cara K Campanaro1, David E Nethery1, Fei Guo2
1Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University, Cleveland, OH, United States.
Frontiers in network physiology
|August 16, 2023
概括
在大鼠中,由脂聚糖 (LPS),改变呼吸模式变异性 (VPV) 和心呼吸器合 (CVC) 诱导的内毒性. 对VPV的非线性复杂性指数 (NLCI) 增加,而CVC下降,表明对败血症诱导的神经炎症的敏感性.
科学领域:
- 生理学 生理学 生理学
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 生理信号提供了对健康状况的见解.
- 呼吸器模式变化 (VPV) 和心肺呼吸器合 (CVC) 是重要的生物识别指标.
- 内毒素症可以诱导神经炎症,可能会影响这些措施.
研究的目的:
- 为了研究VPV和CVC对内毒素的敏感性.
- 评估脂多糖 (LPS) 对神经炎症和呼吸/心脏生物识别的影响.
- 评估非线性复杂性指数 (NLCI) 作为衡量VPV变化的指标.
主要方法:
- 在老鼠身上植入了血压 (BP) 传感器.
- 透气波形和血压被用全身囊造影记录下来.
- 在3天内内内注射LPS或盐水,随后对VPV,CVC和心率变化 (HRV) 进行分析.
主要成果:
- 心率 (HR) 和呼吸频率 (fR) 增加,而在接受LPS治疗的老鼠中,CVC下降.
- 衡量VPV的NLCI增加,表明波形可预测性更高.
- 血压和HRV光谱成分 (LF,HF) 没有显著变化;肺损伤和呼吸核中的IL-1β得到证实.
结论:
- NLCI有效地反映了由LPS诱导的内毒素引起的健康变化.
- 在VPV和CVC的变化是系统性炎症和神经炎症的敏感指标.
- NLCI可能代表炎症性细胞因子对呼吸控制网络的影响.
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