前额外影响神经回路的功能,导致灵长类动物的焦虑气
Margaux M Kenwood1, Jonathan A Oler2, Do P M Tromp2
1Department of Psychiatry, Weill Cornell Medicine, New York, NY.
Oxford open neuroscience
|August 16, 2023
概括
前额叶皮层 (PFC) 在调节类似焦虑的行为方面发挥着关键作用. 扰乱轨道前皮层 (OFC) 中的连接改变了与灵长类动物威胁处理相关的神经电路功能.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 灵长类动物模型
背景情况:
- 童年早期的焦虑气是与压力相关的精神病理学的危险因素.
- 前额叶皮层 (PFC) 参与调节情绪反应和威胁反应.
- 了解焦虑的神经电路对于开发有效干预措施至关重要.
研究的目的:
- 调查前额叶皮层 (PFC) 在非人类灵长类动物模型中调节类似焦虑行为的作用.
- 检查轨道前皮层 (OFC) 病变对皮层下焦虑相关神经回路的功能的影响.
- 测试假设,PFC内部的结构连接对于焦虑调节至关重要.
主要方法:
- 在非人类灵长类动物的后轨道前皮层 (pOFC) 上进行了吸气病变.
- 损伤疗效通过评估未切割囊 (UF) 的微观结构完整性来验证.
- 在损伤后测量了与威胁相关的行为和神经电路代谢的变化.
主要成果:
- 病变导致与威胁相关的行为略有下降.
- 在参与威胁处理的大脑区域观察到代谢的大幅下降.
- 病变破坏了未切割囊 (UF) 的结构完整性,这是一个关键的白质道.
结论:
- 对于调节焦虑而言,PFC和皮质下区域之间的结构连接至关重要.
- 轨道前皮层 (OFC) 在调节与焦虑有关的神经回路方面发挥着重要作用.
- 这些发现凸显了PFC介导调节在焦虑表达中的重要性.
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