操纵肠道微生物群 - - 一个缓慢的旅程到黄金时代
Ofra Kriger-Sharabi1, Stephen D H Malnick2, David Fisher3
1Institute of Gastroenterology, Assuta Medical Center, Ashdod 7747629, Israel.
World journal of clinical cases
|August 16, 2023
概括
便微生物种移植是一种长期存在的疗法,它对治疗复发性Clostridioides difficile感染 (CDI) 和其他疾病,如代谢相关脂肪肝疾病 (MAFLD) 的治疗有希望. 本综述探讨了它在各种肠道相关疾病中的作用.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物群在维持正常的身体功能方面发挥着至关重要的作用.
- 消化不良或肠道微生物群的改变越来越多地与各种疾病有关.
- 便微生物种移植 (FMT) 是一种古老的疗法,涉及便物质的转移,以恢复健康的微生物群.
研究的目的:
- 审查当前关于微生物组在特定疾病的发病和治疗中的作用的文献.
- 突出便微生物群移植 (FMT) 在管理各种胃肠道和代谢疾病中的有效性.
主要方法:
- 审查关于肠道微生物组研究的现有科学文献.
- 对不同疾病状态的便微生物群移植 (FMT) 调查研究的分析.
- 综合了有关微生物组参与疾病发展和治疗干预措施的数据.
主要成果:
- 便微生物种移植 (FMT) 对复发性Clostridioides difficile感染 (CDI) 非常有效.
- 新出现的证据表明,FMT在与代谢相关的脂肪肝病 (MAFLD),刺激性肠综合征 (IBS) 和炎症性肠病 (IBD) 中具有有效性.
结论:
- 肠道微生物组是健康和疾病的组成部分.
- 便微生物群移植 (FMT) 代表了对CDI的重要治疗选择,并对其他复杂疾病具有潜力.
- 需要进一步的研究,以充分阐明 FMT 在 MAFLD,IBS 和 IBD 的治疗应用.
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