早期,轻度至中度COVID-19的未接种疫苗的患者中的阿曼塔丁:一种随机,安慰剂控制,双盲试验
Konrad Rejdak1, Piotr Fiedor2, Robert Bonek3
1Department of Neurology, Medical University of Lublin, Lublin, Poland.
European journal of neurology
|August 16, 2023
概括
与安慰剂相比,阿曼塔丁 (AMD) 在早期COVID-19患者的完全康复率高出60%. 这种抗病毒药物可能有助于减少COVID-19的进展和神经症状.
科学领域:
- 病毒学 病毒学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 包括阿曼塔丁在内的阿曼塔丁被考虑为早期COVID-19干预.
- 这项研究旨在评估阿曼塔丁在预防COVID-19进展和神经问题的有效性.
研究的目的:
- 为了评估阿曼塔丁在预防COVID-19进展方面的有效性.
- 评估阿曼塔丁对COVID-19的神经系统后果的影响.
主要方法:
- 最近感染SARS-CoV-2的99名未接种疫苗的患者被随机分配给阿曼塔丁 (100毫克每天两次) 或安慰剂14天.
- 主要结局是使用世卫组织指标尺度 (OSCI-WHO) 的临床改善.
- 其次结果包括疲劳,抑郁,嗅觉/味觉障碍和嗜睡.
主要成果:
- 阿曼塔丁组在第15天的完全康复率高出60% (p=0.025).
- 在两组中都注意到味觉和嗅觉的显著改善,但阿曼塔丁特别改善了抑郁症 (p=0.010) 和嗜睡 (p=0.0002).
- 没有观察到疾病进展的显著差异,尽管安慰剂组在第210天有1例死亡.
结论:
- 在早期的COVID-19患者中,阿曼塔丁可能会支持更快的恢复.
- 阿曼塔丁对中枢神经系统的影响,如减少嗜睡和抑郁症,可能有助于改善结果.
- 阿曼塔丁耐受性良好,没有报告任何重大不良事件.
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