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Dagny Krankowska^1,2, Sebastian Flanczewski³, Wiktoria Gajek-Flanczewska³

¹Department of Infectious and Tropical Diseases and Hepatology, Medical University of Warsaw, Warsaw, Poland.

|August 16, 2023

概括

早期的人类免疫缺陷病毒 (HIV) 诊断和持续的抗逆转录病毒治疗 (ART) 对艾滋病毒 (PLWH) 感染者至关重要. 这项研究发现,活跃药物使用与ART中断有关,而移民则面临延迟的艾滋病毒诊断,突出了针对性干预的需要.

科学领域:

传染性疾病传染性疾病
公共卫生公共卫生
临床医学临床医学

背景情况:

人类免疫缺陷病毒 (HIV) 的早期诊断和持续的护理维持对于改善艾滋病毒感染者 (PLWH) 的治疗结果至关重要.
了解与治疗中断和晚期诊断相关的因素对于有效的艾滋病毒管理策略至关重要.
波兰的医疗保健系统为检查艾滋病毒护理中的这些挑战提供了一个背景.

研究的目的:

为了比较停止抗逆转录病毒治疗 (ART) 的患者和被诊断晚期感染HIV的患者.
为了确定ART中断与HIV晚期诊断的风险因素.
为艾滋病毒护理中的弱势群体提供有针对性的干预信息.

主要方法:

在波兰的一家传染病诊所,从2020-2021年对215名艾滋病毒感染者 (PLWH) 的回顾性分析.
进行了两项子分析:比较治疗中断后重新连接护理的患者 (A组) 与晚期艾滋病毒诊断的患者 (B组),并比较A组与坚持ART的患者 (C组).
使用统计分析,包括双变量和多变量方法,以确定显著的关联.

主要成果:

与晚期艾滋病毒诊断 (p=0.001) 患者相比,停止ART治疗的患者更有可能报告活跃药物使用 (p=0.001).
移民被诊断为晚期感染艾滋病毒的可能性明显高于中断ART,这在双变量 (p=0.004) 和多变量 (p=0.015) 分析中都显示了这一点.
活性药物使用与更高的ART中断风险有关,而女性性别在多变量分析中不是一个显著的因素.

结论:

活跃药物使用是艾滋病毒感染者中断抗逆转录病毒治疗的重要危险因素.
移民人口面临着晚期艾滋病毒诊断的更高风险,需要量身定制的推广和支持.
针对性干预对于有ART中断风险的个人和晚期艾滋病毒诊断患者来说都至关重要,以改善长期健康结果.

关键词:

终止ART的使用吸毒成吸毒成是一种成.晚期的艾滋病毒诊断.

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