酶兼容的核心外纳米反应器用于局部H2 - 驱动NAD(P) H再生
Maodi Wang1,2, Huicong Dai3, Qihua Yang3
1State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China.
Angewandte Chemie (International ed. in English)
|August 16, 2023
概括
这项研究开发了一种核心纳米反应器,用于高效的驱动的尼古丁胺氨基二核酸 (NAD(P) H) 再生. 纳米反应器成功与化学酶还原酶合,展示了合作催化策略.
科学领域:
- 催化剂是一种催化剂.
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
背景情况:
- 尼古丁胺胺氨基二核酸 (NAD(P) H) 的有效再生对于细胞外生物还原应用至关重要.
- 现有的NAD(P) H再生系统往往无法与级联酶化还原过程相兼容.
研究的目的:
- 开发一个高效和兼容的人工NAD(P) H再生催化系统.
- 将金属纳米粒子和金属复合体集成到核心外纳米反应器中,用于驱动的NAD再生.
主要方法:
- 在Ni/TiO2表面上固定 (Rh) 复合物,使用含有双的3D多孔有机聚合物 (POP).
- 一个集成金属纳米粒子 (NP) 和金属复合物的核心外纳米反应器的制造.
- 将纳米反应器与化减少酶 (AKR) 合起来,用于化学酶的减少.
主要成果:
- 与单个组件相比,集成催化剂在NAD(P) H再生中表现出增强的活性和选择性.
- 从金属NP到Rh复合体的活性物种溢出显著改善了催化性能.
- 由于POP的尺寸选效应阻止了酶-催化剂相互作用,使得阿塞托芬的化学酶降解能够成功.
结论:
- 开发的核心外纳米反应器为驱动的NAD再生提供了一个有效的策略.
- 这种方法促进了人工催化剂与酶的成功合,用于化学酶应用.
- 这项研究为多组件合作催化提供了一个合理的设计策略.
相关概念视频
Chemiosmosis and ATP Synthesis
55
The electron transport chain is a critical component of cellular respiration, occurring in the inner mitochondrial membrane. It facilitates the transfer of high-energy electrons from reduced cofactors NADH and FADH₂ to molecular oxygen, the final electron acceptor. This transfer of electrons through a series of protein complexes is tightly coupled to the translocation of protons across the membrane, generating a proton gradient essential for ATP synthesis.Electron Flow and Proton...
55
Role of Reduced Coenzymes NADH and FADH₂
11.9K
The energy released from the breakdown of the chemical bonds within nutrients can be stored either through the reduction of electron carriers or in the bonds of adenosine triphosphate (ATP). In living systems, a small class of compounds functions as mobile electron carriers, molecules that bind to and shuttle high-energy electrons between compounds in pathways. The principal electron carriers that will be considered originate from the B vitamin group and are derivatives of nucleotides; they are...
11.9K
Chemiosmosis
99.5K
Oxidative phosphorylation is a highly efficient process that generates large amounts of adenosine triphosphate (ATP), the basic unit of energy that drives many cellular processes. Oxidative phosphorylation involves two processes— the electron transport chain and chemiosmosis.
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons...
Electron Transport Chain
The electron transport chain involves a series of protein complexes on the inner mitochondrial membrane that undergo a series of redox reactions. At the end of this chain, the electrons...
99.5K
Electron Carriers
85.1K
Electron carriers can be thought of as electron shuttles. These compounds can easily accept electrons (i.e., be reduced) or lose them (i.e., be oxidized). They play an essential role in energy production because cellular respiration is contingent on the flow of electrons.
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
Over the many stages of cellular respiration, glucose breaks down into carbon dioxide and water. Electron carriers pick up electrons lost by glucose in these reactions, temporarily storing and releasing them into the electron...
85.1K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
3.4K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.4K
Redox Reactions
55.8K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
55.8K


