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Updated: Jul 19, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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人类DNA甲基转移酶DNMT1中的突变会诱导神经发育中的特定基因组范围的表观基因组和转录基因组变化

Kasey N Davis1,2, Ping-Ping Qu1,2, Shining Ma3

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA.

Human molecular genetics
|August 16, 2023
PubMed
概括

在DNA甲基转移酶1型 (DNMT1) 中的突变会导致细胞特异性表观遗传和基因表达变化,在患有自体主导大脑,聋和麻醉症 (ADCA-DN) 的患者中. 这些发现揭示了对DNMT1功能和ADCA-DN病原体的分子洞察力.

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