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妊娠引起的GDF15跨物种比较

Anders Bue Klein¹, Pablo Ranea-Robles¹, Trine Sand Nicolaisen^1,2

¹Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

American journal of physiology. Endocrinology and metabolism

|August 16, 2023

概括

增长分化因子15 (GDF15) 在人类和的怀孕期间显著增加,但在动物中显示出最小的变化. 这个物种特定的答案问题 GDF1515

科学领域:

生殖生物学生殖生物学
内分泌学在内分泌学.
分子生物学分子生物学

背景情况:

增长分化因子15 (GDF15) 是一种由压力诱导的细胞因子,涉及到妊娠并发症,如妊娠激发 (HG).
遗传研究将GDF15及其受体GFRAL与人类怀孕期间的恶心和吐联系起来.

研究的目的:

在不同物种中调查和比较妊娠引起的GDF15水平的变化.
评估GDF15在动物,和人类怀孕中的生理相关性.

主要方法:

在怀孕的小鼠,老鼠,和人类中量化循环GDF15水平.
从这些物种的胎盘组织中分析GDF15mRNA和蛋白质表达.

主要成果:

人类和在怀孕期间血GDF15显著增加 (高达75倍).
动物 (老鼠和大鼠) 在怀孕期间GDF15水平仅略有增加 (约2倍).
胎盘GDF15表达反映了循环水平,在和人类有显著的诱导,但不是动物.

结论:

GDF15在人类和的怀孕中起着重要作用,其水平显著增加.
怀孕动物中GDF15的微不足道升高表明这些物种的生理作用有限.
这些发现突出了特定物种的GDF15反应,影响了未来对GDF15-GFRAL信号传递的研究,用于治疗与怀孕有关的恶心和HG.

关键词:

在GDF15中,GDF15是GDF15中的一个.恶心恶心恶心胎盘胎盘胎盘胎盘怀孕怀孕怀孕怀孕怀孕它们是灵长类的灵长类.

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