美国COVID-19相关并发症的肺移植后的结果
Panagiotis Tasoudis1, Leonard J Lobo2, Raymond D Coakley2
1Department of Surgery, Division of Cardiothoracic Surgery, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill.
JAMA surgery
|August 16, 2023
概括
肺移植为患有严重COVID-19肺损伤的患者提供了一种拯救生命的选择. 与COVID-19相关的急性呼吸窘迫综合征或肺纤维化症患者的肺移植结果与其他原因相似.
科学领域:
- 肺部病理学 肺部病理学
- 移植手术 移植手术
- 关键护理医学 关键护理医学
背景情况:
- 由于COVID-19大流行,肺部不可逆转的损伤需要进行肺移植.
- 关于COVID-19患者肺移植结果的数据有限.
研究的目的:
- 描述COVID-19相关的急性呼吸窘迫综合征 (ARDS) 或肺纤维化肺移植后的结果.
主要方法:
- 一项队列研究分析了美国联合器官共享网络数据库 (2020年3月-2022年8月) 的数据.
- 包括385名肺移植接受者,患有COVID-19相关的ARDS或肺纤维化.
- 卡普兰-梅尔和考克斯的比例回归模型评估了整体存活率和移植失败.
主要成果:
- 在COVID-19 ARDS和肺纤维化队列中,1个月,6个月和12个月的整体存活率和移植失败率相似.
- 特定的捐赠者和接受者因素与每个队列的生存有关 (例如,ARDS中吸烟史,接受者/捐赠者的性别和纤维化中的BMI).
- 在两组中,急性排斥率低且相似 (8.7%对8.6%).
结论:
- 肺移植是由于COVID-19导致的不可逆转的呼吸衰竭的可行治疗方法.
- 结果似乎与其他先前存在的疾病的肺移植相似.
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