使用修改后的治疗和延长协议治疗新血管与年龄相关的黄斑退化症的临床结果
Brice Nguedia Vofo1, Yaacov Cnaany1, I Chowers2
1Ophthalmology, Hadassah Medical Center, Jerusalem, Israel.
BMJ open ophthalmology
|August 16, 2023
概括
对新血管与年龄相关的黄斑变性进行修改的治疗和延长 (mT&E) 协议,提供与传统的T&E协议相似的视觉和解剖结果. 该mT&E方法显著减少了临床访问时间,节省了患者宝贵的时间.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 临床试验 临床试验
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 需要持续治疗,通常涉及频繁的临床访问.
- 治疗和延长 (T&E) 协议是nAMD的常见管理策略.
- 优化临床访问频率和持续时间对于患者管理和医疗保健资源利用至关重要.
研究的目的:
- 为了在nAMD患者中比较修改后治疗和扩展 (mT&E) 协议与传统的T&E协议的疗效和效率.
- 为了评估视觉和解剖学的结果超过36个月.
- 评估mT&E协议对临床访问时间和患者时间的影响.
主要方法:
- 一个回顾性队列研究,比较两组以前未接受过治疗的nAMD患者.
- 传统的T&E组:视力敏度,扩展底部检查 (DFE) 和光学连贯性断层扫描 (OCT) 在每次访问.
- mT&E组:视力敏度和每三次访问一次的DFE,OCT可能不太频繁.
- 主要结果指标:每次访问的时间,视力敏度 (ETDRS字母) 和OCT定义的36个月的解剖变化.
主要成果:
- 在T&E和mT&E组之间,在36个月内注射次数,视力增长 (≥15个ETDRS字母) 或视力损失 (≥15个ETDRS字母) 没有显著差异.
- 该mT&E协议导致等待和接触时间的显著减少,在仅在OCT访问期间,每次患者接触平均节省了41分钟.
- 两组患者的基线特征相似.
结论:
- 传统的T&E和mT&E协议在nAMD管理中实现了可比的视觉和解剖结果.
- 通过减少全面临床评估的频率,mT&E协议提供了一种更具时间效率的方法.
- mT&E代表了对nAMD治疗的可行替代方案,有可能改善患者的便利性和诊所的工作流程.
更多相关视频
05:14Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
1.1K
10:14Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
3.3K
相关概念视频
01:27Open Angle Glaucoma: Treatment
479
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
479
01:28Angle Closure Glaucoma: Treatment
560
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
560
01:25Glaucoma: Overview
621
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
621
01:26Atherosclerosis III: Management
12
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
12
01:26Peripheral Artery Disease IV: Nursing Management
12
The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
12