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Updated: Jul 19, 2025

All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System
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All-optical Mechanobiology Interrogation of Yes-associated Protein in Human Cancer and Normal Cells using a Multi-functional System

Published on: December 20, 2021

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Frizzled-9触发了actin聚合,并激活了机械传感器YAP,以拯救模拟的微重力诱导的骨质细胞功能障碍

Qiusheng Shi1, Jinpeng Gui1, Lianwen Sun1

  • 1Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|August 16, 2023
PubMed
概括

Frizzled-9 (Fzd9) 蛋白质有助于骨细胞在模拟的微重力条件下发挥作用. 过度表达Fzd9通过促进乙聚合和YES相关蛋白 (YAP) 核转移来拯救骨质细胞功能障碍,这表明Fzd9是太空飞行引起的骨损失的治疗标.

关键词:
这就是 Frizzled-9的原因.哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈核孔是一个核孔.骨质细胞功能障碍 骨质细胞功能障碍在模拟的微重力环境中进行模拟.

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