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Updated: Jul 28, 2026

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通过WNK激酶进行水静压传感

John M Humphreys1, Liliana R Teixeira1, Radha Akella1

  • 1Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX 75390.

Molecular biology of the cell
|August 16, 2023
PubMed
概括

水位压力改变了WNK3 (没有氨酸激酶3) 的结构,从二聚体变成单聚体,影响了它的活性. 这揭示了WNK激酶如何感知和响应物理力量的新机制.

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Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin homology) domains...