暴露于极端温度和早产子类型的风险,基于中国全国调查
Guoqi Yu1, Ling Yang2, Ming Liu3
1Ministry of Education - Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Environmental health perspectives
|August 16, 2023
概括
极端寒冷增加了早产 (PTB) 的风险,特别是晚期和自发的PTB. 这种关联在中国北部/西部和女性胎儿中更为强烈,对于热浪没有发现任何联系.
科学领域:
- 环境流行病学环境流行病学
- 围产期健康 围产期健康
- 气候变化影响 气候变化影响
背景情况:
- 环境温度会影响围产期的结果,但极端温度对早产风险的影响仍在争论中.
- 对极端温度和PTB亚型的研究有限.
研究的目的:
- 调查极端气候事件与PTB风险之间的关联,包括亚型.
- 确定这些关联中的潜在改变因素.
主要方法:
- 利用来自中国劳动和分娩调查 (2015-2016) 的单独分娩数据.
- 定义的PTB和分类的亚型:早期,晚期,自发性,PPROM和阳性.
- 分析了使用通用线性混合和考克斯回归模型对极端温度 (热浪,寒流) 的短期产前暴露.
- 根据区域和胎儿性别进行了分层分析.
主要成果:
- 在分娩前1-2周暴露于极端寒冷时期显著增加了PTB风险.
- 感冒症状与晚期PTB,自发PTB和晚期PPROM有更强的关联.
- 关联在西部和北部地区以及女性胎儿中更为明显.
- 热浪和PTB之间没有发现显著的关联.
结论:
- 感冒与增加PTB风险有关,特别是自发PTB和PPROM.
- 地理区域 (北/西) 和胎儿的性别 (女性) 改变了对寒冷的易感性.
- 怀孕晚期的孕妇更容易受到极端温度的影响.
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