素饮食通过调节肠道微生物群,改善了老鼠的注意力缺陷多动症
Yu Liu1, Changhong Yang1, Yingxue Meng1
1Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
PloS one
|August 16, 2023
概括
性饮食 (KD) 可能为注意力缺陷多动症 (ADHD) 提供一种新的治疗方法. 这种饮食改变了肠道微生物群和大脑化学,可能减轻大鼠的ADHD类行为.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 营养精神病学 营养精神病学
背景情况:
- 注意缺陷多动症 (ADHD) 是儿童普遍存在的行为障碍.
- 肠道微生物群的变化越来越多地与神经和行为障碍有关.
- 饮食干预措施的潜力,如性饮食 (KD),对于ADHD需要进行调查.
研究的目的:
- 调查基因饮食 (KD) 作为ADHD的替代疗法的疗效.
- 在ADHD小鼠模型中探索KD对肠道微生物群组成和大脑化学的影响.
- 为了确定KD诱导的肠道微生物群的变化是否与行为改善相关.
主要方法:
- 雄性自发高血压大鼠 (SHR) 和Wistar京都 (WKY) 大鼠被分配到正常饮食 (ND),甲基化物 (MPH) 或KD组.
- 进行了行为评估,脑组织分析 (神经递质,蛋白质表达) 和肠道微生物群分析.
- 分析了肠道微生物群多样性,丰富性和特定细菌种群的变化.
主要成果:
- 在SHR中,KD和MPH治疗都显著增加了类似ADHD的行为.
- 凯迪和MPH增加了脑中血清素 (5-HT),多巴胺和北上腺素 (NE) 的度,以及关键蛋白质的表达.
- 在SHR中,KD显著增强了肠道微生物群的丰富性和多样性,改变了特定细菌和代谢途径的丰富性.
结论:
- 性饮食 (KD) 可能成为ADHD的潜在治疗策略.
- 肠道疾病影响肠道微生物组成和大脑神经化学,这表明在ADHD中存在肠-大脑轴连接.
- 进一步研究KD治疗ADHD的研究得到了这些发现的支持.
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