在阶梯形设计中,集群的最佳配置具有衰变的关联结构
1Department of Methodology and Statistics, Utrecht University, Utrecht, The Netherlands.
PloS one
|August 16, 2023
概括
这项研究优化了阶段形设计中的集群分配,发现不均的分布,有利于早期或晚期交换机,往往更有效. 在大多数情况下,统一分配仍然非常有效.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
- 临床试验 临床试验
背景情况:
- 集群随机阶段形设计是评估干预措施的强大工具.
- 统一分配是常用的,但可能不是统计学上最有效的.
- 优化集群分配可以提高学习能力和资源利用率.
研究的目的:
- 在集群随机阶段形设计中推导集群对处理序列的最佳分配.
- 为了将最佳分配与统一分配进行对比,对于队列和横截面设计.
- 调查自相关结构对最佳集群分配的影响.
主要方法:
- 为阶段形设计推导最佳集群分配公式.
- 在指数衰减相关结构下的分析.
- 对类内相关系数和自相关系数的敏感度的评估.
主要成果:
- 最佳分配取决于类内相关性,每个集群时期的受试者和自相关系数.
- 对于小到中等的自相关性,具有早期或迟切换的序列会收到更多的集群.
- 随着自身相关性增加,集群倾向于在序列中更加平等地分布.
结论:
- 阶梯设计中的最佳集群分配并不总是统一的.
- 在大多数研究的场景中,均分配显示出高效率 (≥0.8).
- 提供R代码来实现衍生的最佳分配策略.
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