较高的牛奶消费与较低的糖尿病风险有关:一个病例对照研究
Pornthep Tanpowpong1, Wichai Aekplakorn2, Suwat Chariyalertsak3
1Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailandand.
PloS one
|August 16, 2023
概括
乳糖酶不持久性在泰国非常普遍,但基于这种遗传特征,牛奶消费量没有显著差异. 更高的牛奶摄入量与降低患糖尿病的风险有关.
科学领域:
- 遗传学 是一个遗传学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 乳糖不持续性与较低的乳制品摄入量和非传染性疾病风险增加有关.
- 胰岛素抵抗与乳糖酶不持久性有关.
- 发展中国家乳糖不持续性和乳制品摄入量数据有限.
研究的目的:
- 为了确定乳糖酶不持久性在泰国糖尿病和没有糖尿病的个体中的患病率.
- 在泰国调查乳糖不持续性,牛奶消费和糖尿病风险之间的关系.
主要方法:
- 一项病例控制研究利用了来自国家健康检查调查的数据.
- 在DNA分析中发现了LCT -13910C>T (rs4988235) 多态.
- 1756名患有糖尿病的参与者 (病例) 与2380名没有糖尿病的参与者 (对照) 进行了比较.
主要成果:
- 该研究包括4136名参与者,主要是女性,年龄超过30岁.
- 乳糖酶不持久性 (CC基因型) 在98.6%的参与者中被发现.
- 尽管乳糖不持久性高,但较高的牛奶消费与较低的糖尿病风险相关 (P = .01).
结论:
- 乳糖酶不持久性的患病率在泰国人口中非常高.
- 根据乳糖不持续状态,没有观察到牛奶消费频率的显著差异.
- 增加牛奶消费与糖尿病风险降低有关.
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