肠道微生物群有助于改变由Trichinella spiralis诱导的宿主免疫反应
Chengyao Li1, Yi Liu1, Xiaolei Liu1
1State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
PLoS neglected tropical diseases
|August 16, 2023
概括
三螺旋菌感染破坏了肠道微生物群的多样性,损害了免疫反应和寄生虫的驱逐. 通过便移植恢复肠道细菌可以改善寄生虫清除,强调微生物群在宿主防御中的作用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 寄生虫学的寄生虫学
背景情况:
- 肠道微生物群对于宿主-寄生虫相互作用和免疫反应至关重要.
- 三螺旋菌是影响肠道环境的显著动物性寄生虫.
- 了解T. spiralis感染期间的微生物群变化是主机防御的关键.
研究的目的:
- 为了研究由T. spiralis感染引起的肠道微生物群变化.
- 确定肠道微生物群在宿主免疫防御和寄生虫驱逐中的作用.
- 阐明微生物群干扰对免疫细胞群和细胞因子生产的影响.
主要方法:
- 用于肠道微生物群分析的16S rRNA测序.
- 在小鼠中进行抗生素治疗 (ABX) 和便细菌移植 (FMT).
- 流细胞计,qPCR和代谢学来评估免疫反应和代谢物.
主要成果:
- 螺旋菌感染减少了肠道微生物群的多样性,而后感染后的微生物群恢复.
- 接受抗生素治疗的小鼠表现出较高的寄生虫负担;FMT减少了负担.
- 微生物群的干扰损害了CD4+T细胞的比例,IL-4的产生,并削弱了Th2的反应,阻碍了寄生虫的驱逐.
- 观察到减少炎症和Th1反应与微生物群的变化,在ABX小鼠中较低的陶胺水平.
结论:
- 螺旋菌感染显著改变肠道微生物群的组成和结构.
- 肠道微生物群对于有效的免疫反应和寄生虫驱逐至关重要.
- 调节肠道微生物群有可能通过影响宿主免疫力来控制T. spiralis感染.
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