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Updated: Jul 19, 2025

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对三种Y形联体与PI3Kα的相互作用的结构见解

Qingtong Zhou1, Xiao Liu1, Dario Neri2

  • 1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Proceedings of the National Academy of Sciences of the United States of America
|August 16, 2023
PubMed
概括

新的Y形联体以独特的方式与酸酸3-酶α (PI3Kα) 结合,为癌症药物开发提供了一种新的策略. 这些化合物避免了与当前PI3Kα抑制剂相关的典型安全问题.

关键词:
绑定的口袋绑定方式化学的脚手架 化学的脚手架药物目标是药物目标.连接器连接器连接器氏酸3-酶酶的使用方法

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