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相关概念视频

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
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Inflammation01:38

Inflammation

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Overview
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Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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相关实验视频

Updated: Jul 19, 2025

Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
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Quantification of Efferocytosis by Single-cell Fluorescence Microscopy

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针对在炎症中引起的细胞增生.

Ivan K H Poon1, Kodi S Ravichandran2,3

  • 1Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, and Research Centre for Extracellular Vesicles, La Trobe University, Melbourne, Victoria, Australia;

Annual review of pharmacology and toxicology
|August 16, 2023
PubMed
概括

有效的细胞分裂能清除亡细胞,保持组织健康. 损伤的细胞效应,或者说,细胞无法清除细胞残渣,导致慢性炎症和与衰老相关的疾病.

关键词:
老化的老化 衰老的老化灭症 (apoptosis) 是一种死亡的过程.细胞清除的时间细胞死亡是细胞死亡.这种细胞的形成是Efferocytosis.炎症导致的炎症.

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A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
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相关实验视频

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科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 老年学是一门学科.

背景情况:

  • 细胞分裂 (efferocytosis),即细胞对亡细胞的清除,对于组织平衡和炎症解消至关重要.
  • 缺陷的乙细胞分裂会导致死亡细胞的积累,释放炎症因素并导致无菌炎症.
  • 这种受损的清除与炎症有关,慢性低度炎症与衰老有关.

研究的目的:

  • 检查底层的分子机制的检测,吸收和降解阶段的细胞.
  • 讨论细胞和细胞的变化如何导致细胞缺陷.
  • 探索针对细胞的治疗策略,以对抗与衰老相关的炎症性疾病.

主要方法:

  • 关于分子机制的文献综述 在Efferocytosis中.
  • 分析了细胞和亡细胞变化的作用在细胞功能障碍中的作用.
  • 在细胞通路内探索潜在的治疗点.

主要成果:

  • 详细的分子途径用于细胞亡的细胞检测,吞和细胞的降解被阐明.
  • 鉴定出了致病细胞和垂死细胞中的特定缺陷,这些缺陷有助于致病细胞的衰弱.
  • 埃弗罗细胞分裂功能障碍和炎症之间的联系得到了加强.

结论:

  • 了解埃弗罗细胞分裂的分子基础是解决其失败的关键.
  • 准乳细胞机械为治疗与年龄相关的炎症疾病提供了有前途的途径.
  • 控制细胞增生可以减轻炎症对健康的影响.