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Updated: Jul 10, 2026

Candida albicans Biofilm Chip CaBChip for High-throughput Antifungal Drug Screening
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界面过活化Candida rugosa的脂酶到Ca2Fe2O5纳米粒子:pH和离子强度微调调以调节蛋白质支持相互作用

Andrés H Morales1, Johan S Hero1, Ana E Ledesma2

  • 1Planta Piloto de Procesos Industriales Microbiológicos PROIMI-CONICET, Av. Belgrano y Pasaje Caseros, Tucumán T4001 MVB, Argentina.

Langmuir : the ACS journal of surfaces and colloids
|August 16, 2023
PubMed
概括

这项研究详细介绍了Candida rugosa脂酶 (CRL) 在氧化铁纳米颗粒上的固定. 在pH 4和50 mM的离子强度下发生了最佳固定,但在pH 4和150 mM观察到最大的酶活性,这表明过度激活.

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相关概念视频

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...