欧基尼亚单花:对抗多药耐药细菌的一种有希望的天然替代品
M R A Ferreira1, L B Lima1, E C F Santos1
1Universidade Federal de Pernambuco, Departamento de Ciências Farmacêuticas, Laboratório de Farmacognosia, Recife, PE, Brasil.
Brazilian journal of biology = Revista brasleira de biologia
|August 16, 2023
概括
尤金尼亚单花叶提取物显示出抗氧化和抗菌性质. 它的丰富分量增强了抗生素对抗多药耐药细菌的有效性,提供了一个有前途的天然替代品.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 多药耐药 (MDR) 细菌构成了严重的全球健康威胁.
- 天然产品,如尤金尼亚单一花的提取物,正在探索新型抗菌剂.
- 了解植物提取物的化学成分和生物活性对于药物发现至关重要.
研究的目的:
- 为了评估Eugenia uniflora Linn.的化学成分,抗氧化剂和抗菌活性. 叶子提取物. 叶子提取物.
- 为了研究Eugenia uniflora提取物与抗生素结合对抗MDR细菌的潜力.
- 确定负责观察到的生物活性的关键化合物.
主要方法:
- 通过轮提取进行原油提取,然后进行分化.
- 用于化合物识别的染色学分析 (酸,酸,米里素).
- 使用DPPH•和ABTS•+试验评估的抗氧化能力.
- 通过最小抑制/杀菌度 (MIC/MBC) 确定对22种细菌菌株的抗菌活性.
- 协同效应使用检查板和模块化试验与抗生素对抗MDR菌株进行评估.
主要成果:
- 尤金亚单花生原料提取物和乙酸盐分离物 (EAF) 显示出抗氧化活性,与黄含量有关.
- 在EAF表现出抗微生物活性,特别是针对格拉姆阳性菌株.
- EAF与西普罗素和热胺素的组合显示出对抗耐药菌株的协同作用,包括Pseudomonas aeruginosa.
- 鉴定出了酸,酸和基,在EAF中进行缩.
结论:
- 尤金尼亚单花叶提取物及其EAF具有显著的抗氧化和抗菌特性.
- 在EAF显示潜在的辅助疗法,以对抗MDR细菌感染.
- 黄酸和酸有助于观察到的生物活性,突出了尤金尼亚单花作为天然治疗剂的来源.
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