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在临床实践中定义综合性疾病控制以作为性结肠炎的治疗目标:国际德尔菲共识建议
Stefan Schreiber1, Silvio Danese2, Axel Dignass3
1University Hospital Schleswig-Holstein, Department of Internal Medicine I, Kiel, Germany.
Journal of Crohn's & colitis
|August 16, 2023
概括
对于性结肠炎 (UC) 的综合性疾病控制的新定义现在包括患者报告的症状以及临床措施. 这种以患者为中心的方法旨在改善临床实践和性结肠炎试验中的治疗目标.
科学领域:
- 胃肠病学 胃肠病学
- 临床试验设计 临床试验设计
- 患者报告的结果
背景情况:
- 目前的性结肠炎 (UC) 治疗目标往往忽视了患者的经验.
- 为了有效的UC管理,需要以患者为中心的全面疾病控制定义.
- 经典试验的终点可能无法从患者的角度完全捕捉疾病控制.
研究的目的:
- 在性结肠炎 (UC) 疾病控制的全面定义上达成共识.
- 将患者报告的方面与UC的传统临床措施相结合.
- 为UC治疗目标建立以患者为中心的框架.
主要方法:
- 一个经过修改的Delphi过程,涉及12位胃肠科医生和1位患者倡导者.
- 收集了18名患者和小组成员关于缓解经验的输入.
- 匿名投票在三轮投票中进行,在最后一轮之前进行现场讨论.
主要成果:
- 在结合临床试验测量 (出血,便频率,QoL,内镜,组织学,生物标志物,类固醇) 与患者报告的症状 (紧急性,疼痛,疲劳,睡眠,肠外表现) 的定义上达成共识.
- 关于许多定义的方面的评分系统和值的协议.
- 一个全面的疾病控制定义,用于UC的个体患者利益.
结论:
- 一种强有力的方法产生了对性结肠炎 (UC) 综合疾病控制的新定义.
- 未来的工作将开发一个多元组件工具来测量和评分这些方面.
- 新的定义将在临床实践和UC试验中被采用为治疗目标.
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