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Updated: Jul 19, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
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Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes

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用电子调节的基激素催化剂对酒精的基保护组进行氧化去保护

Shohei Hamada1, Maiko Sumida1, Rikako Yamazaki1

  • 1Laboratory of Pharmaceutical Chemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.

The Journal of organic chemistry
|August 16, 2023
PubMed
概括

一种新的基基催化剂1在温和条件下有效地去除基保护基. 这种新方法比TEMPO等现有催化剂对各种基板提供了优势.

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Radical Oxidation of Allylic and Benzylic Alcohols

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All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
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