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Updated: Jul 19, 2026

Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits
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Scalable Fluidic Injector Arrays for Viral Targeting of Intact 3-D Brain Circuits

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使用细胞特异性快速放松光开器对多巴胺D2类受体进行光学控制

Belinda E Hetzler1, Prashant Donthamsetti2, Zisis Peitsinis1

  • 1Department of Chemistry, New York University, New York, New York 10003, United States.

Journal of the American Chemical Society
|August 16, 2023
PubMed
概括

科学家们开发出一种新型的光开关来精确控制大脑中的多巴胺D2类受体 (D2R,D3R,D4R). 这一突破允许针对性激活或阻断这些受体用于潜在的神经精神疾病治疗.

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A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

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Optical Control of a Neuronal Protein Using a Genetically Encoded Unnatural Amino Acid in Neurons

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相关概念视频

G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...