扩散性质瘤引起的结构重组与先前存在的语法相关网络密切相关
Ryuta Kinno1, Yoshihiro Muragaki2, Takashi Maruyama2
1Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan; Division of Neurology, Department of Internal Medicine, Showa University Northern Yokohama Hospital, Yokohama, Japan.
概括
左半球的扩散性质瘤可以通过影响特定大脑通道和皮质区域的结构变化,影响语法相关网络,从而导致语法理解.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 左额叶皮层中的质瘤与语法理解和语法网络中的功能连接性改变有关.
- 预先存在的语法网络对质瘤造成的结构重组的影响尚不清楚.
研究的目的:
- 研究质瘤患者的结构性大脑变化及其对语法相关网络的影响之间的关系.
- 确定特定大脑区域和区域的结构变化是否与语法理解有关.
主要方法:
- 基于感兴趣的区域的病变症状映射 (RLSM) 以确定病变位置.
- 基于表面的形态测量 (SBM) 使用MRI来评估皮质厚度和碎形维度.
- 在扩散MRI上进行纤维跟踪,以分析语法网络中的结构连接.
主要成果:
- 语法理解与左内囊的后肢质瘤有关.
- 皮层厚度降低和/或右后半岛复杂性增加与语法理解和语法能力相关.
- 光纤跟踪证实,受影响的路径集成到先前存在的语法相关网络中.
结论:
- 扩散性质瘤可以通过特定大脑通道和皮层区域的结构变化导致对语法理解.
- 这些结构变化与大脑内在的语法相关网络密切相关.
- 这些发现突出了脑瘤,结构性神经可塑性和语言处理之间的相互作用.
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