在患有非静脉性宫动脉样硬化疾病的患者中发生皮下心脏病发作
Jared Wolfe1, Scott Kamen1, Manisha Koneru1
1Cooper Medical School of Rowan University, Camden, NJ, United States.
概括
非石性带斑在与密码性中风,特别是较大的中风相同的侧面更为常见. 这一发现表明,非质性斑块可能导致大约三分之一的单侧前皮下心脏病发作.
科学领域:
- 神经学 神经学
- 血管神经学 血管神经学
- 脑血管疾病 脑血管疾病
背景情况:
- 之前的研究将非质性斑块与皮质密码性心脏病发作联系起来.
- 宫内动脉 (ICA) 斑块在皮下密码性心脏病发作模式中的非静脉性宫内动脉 (ICA) 斑块的作用尚不清楚.
研究的目的:
- 为了研究非静脉性宫内动脉 (ICA) 斑块和皮下密码性心脏病发作之间的关联.
- 为了确定斑块的横向性 (心脏病发作的ipsilateral vs. contralateral) 是否重要.
主要方法:
- 进行了对前部,单侧,皮下心脏病发作和没有确定的栓塞源的患者的嵌套队列研究.
- 排除了>50%的额外缩或心脏栓塞来源的患者.
- 计算机断层扫描血管造影用于评估宫ICA斑块,比较缺口与非缺口心脏病发作模式.
主要成果:
- 在141名符合条件的患者中,41.1%的患者患有ipsilateral nonstenotic斑块,而29.1%的患者患有 contralateral斑块 (p=0.03).
- 这种关联在非缺口性心脏病发作 (49.2%的ipsilateral vs. 14.8%的 contralateral,p<0.001) 中显著,但在缺口性心脏病发作 (35.0% vs. 40.0%,p=0.51) 中没有显著.
结论:
- 在患有皮下密码性中风的患者中,ipsilateral nonstenotic 冠状动脉斑块比 contralateral 斑块更有可能出现.
- 这种关系是由较大的,非缺口的皮下心脏病发作驱动的.
- 非静脉性ICA斑块可能是大约三分之一的单侧前皮下心脏病发作的原因.
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