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关于细颗粒物和COVID-19的传播和严重性:一个体外毒理学可信的机制
S Marchetti1, M Gualtieri1, A Pozzer2
1POLARIS Research Centre, Dept. of Earth and Environmental Sciences, University of Milano-Bicocca, Italy.
细颗粒物 (PM2.5) 暴露可能会使COVID-19恶化. PM2.5增加病毒进入肺细胞并促进炎症,可能增加感染率和疾病严重程度.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 传染病流行病学 传染病流行病学
背景情况:
- COVID-19大流行突显了SARS-CoV-2对全球公共卫生的重大影响.
- 虽然病毒传染性是关键,但环境因素可能会影响COVID-19的发病率和死亡率.
- 空气污染已被调查为SARS-CoV-2传播和疾病严重性的潜在因素.
研究的目的:
- 调查微细颗粒物 (PM2.5) 可能影响SARS-CoV-2感染率和COVID-19严重性的体外毒理机制.
主要方法:
- 在体外对PM2.5对人类肺膜细胞影响的毒理学评估.
- 血管酶转化酶2 (ACE2) 表达的量化.
- 测量RAB5蛋白水平以评估病毒进入.
- 分析炎症标志物,包括介质素-8 (IL-8) 和核因子-kappa B (NF-kB).
主要成果:
- 暴露于PM2.5导致ACE2表达的增加1.5倍.
- 在RAB5蛋白的1.5倍增加表明病毒进入肺细胞的增强.
- 暴露于PM2.5增加了炎症标志物,特别是IL-8和NF-kB蛋白表达.
结论:
- 细颗粒物 (PM2.5) 可能通过特定的毒理途径促进SARS-CoV-2感染并增加COVID-19的严重程度.
- 结果表明,空气污染物与像SARS-CoV-2这样的生物威胁之间存在潜在的协同作用.
- 需要进一步的研究来了解空气质量对未来流行病的影响.
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