在患有2型糖尿病的患者中评估肝纤维化,有或没有慢性病
Therese Adrian1,2, Mads Hornum1,2, Filip Krag Knop2,3,4,5
1Department of Nephrology, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.
Nephron
|August 16, 2023
概括
这项研究发现,在2型糖尿病患者中,肝纤维化和慢性病 (CKD) 之间没有强烈的独立联系. 非酒精性脂肪性肝病 (NAFLD) 的患病率凸显了进一步研究的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 非酒精性脂肪肝 (NAFLD) 影响全球四分之一的人口.
- 肝纤维化是NAFLD的并发症,是慢性病 (CKD) 的潜在危险因素.
- 了解NAFLD-CKD联系至关重要,特别是在2型糖尿病患者中.
研究的目的:
- 调查2型糖尿病患者肝纤维化和CKD之间的关联.
- 为了比较过渡性弹性图 (FibroScan®) 的诊断准确性,FIB-4得分和NAFLD纤维化得分 (NFS) 在这个人群中用于肝纤维化.
主要方法:
- 一项横截面研究包括100名2型糖尿病患者,分为CKD阶段3-5 (N=50) 和非CKD (N=50) 组.
- 结核病的定义是估计的膜过率<60毫升/分钟/1.73米2,有或没有蛋白尿.
- 使用FibroScan® (≥8 kPa),FIB-4得分 (≥2.67) 或NFS (>0.675) 评估显著的肝纤维化.
主要成果:
- 在38%的CKD患者和28%的非CKD患者中,通过至少一种方法检测到显著的肝纤维化.
- 在CKD患者中,FIB-4分数和NFS最初较高,但在对共变量进行调整后变得无意义.
- 在没有CKD的患者中观察到肥胖症和纤维化之间存在显著的关联.
结论:
- 该研究没有发现2型糖尿病患者肝纤维化和已确定的CKD之间存在强烈的独立关联.
- 过渡性弹性图,FIB-4分数和NFS在这个队列中没有显示出强大的独立链接到CKD.
- 需要进一步的研究来澄清NAFLD,肝纤维化和CKD之间的关系.
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