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Updated: Jul 19, 2025

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NSUN2是一种抑制cGAS/STING的葡萄糖传感器,以维持瘤发生和免疫疗法耐药性

Tingjin Chen1, Zhi-Gang Xu2, Jie Luo1

  • 1Department of Cancer Biology, Wake Forest Baptist Medical Center, Wake Forest University, Winston-Salem, NC 27157, USA.

Cell metabolism
|August 16, 2023
PubMed
概括

葡萄糖通过激活甲基转移酶NSUN2作为信号分子,促进癌症生长和免疫治疗耐药性. 抑制这种葡萄糖-NSUN2-TREX2通路可以抑制瘤并提高抗PD-L1疗法的有效性.

关键词:
在NSUN2中,NSUN2是NSUN2.刺痛是一种刺痛.透T细胞的透情况这就是TREX2的特点.cGAS 是一个气体.葡萄糖 葡萄糖 葡萄糖 是 一种免疫疗法耐药性 免疫疗法耐药性m(5)CRNA甲基化

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