小的胎儿胸腺和不良的周产期结局在孕产妇血管炎:一个前性病例控制研究研究
Deniz Oluklu1, Dilek Menekse Beser1, Derya Uyan Hendem1
1Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey.
Journal of gynecology obstetrics and human reproduction
|August 16, 2023
概括
孕产妇的血管炎与小小的胎儿胸腺大小有关. 胎儿胸比率 (TTR) 降低可能表明产周不良结果,有助于怀孕女性血管炎的临床预测.
科学领域:
- 围产儿医学 围产儿医学
- 类风湿病学 类风湿病学
- 医疗成像医学成像
背景情况:
- 胎儿胸腺大小的超声波是由血管炎复杂的怀孕中不良围产期结果的潜在预测因素.
- 怀孕期间的血管炎对胎儿健康构成独特的挑战.
研究的目的:
- 为了比较患有血管炎的孕妇与健康对照群之间的胎儿胸腺大小,用胸腺胸部比率 (TTR) 测量.
- 为了确定胎儿TTR是否可以预测孕妇血管炎的孕妇的不良产周结果.
主要方法:
- 一项病例控制研究,涉及22名患有血管炎的孕妇 (包括贝赫特病,塔卡亚苏动脉炎,维格纳粒状炎) 和66名健康对照.
- 胎儿胸腺大小通过超声波在三血管和气管视图中使用胸腺胸部比率 (TTR) 进行评估.
- 孕期年龄在病例和对照组之间匹配.
主要成果:
- 胎儿TTR在血管炎组 (0.32 ± 0.03) 与对照组 (0.36 ± 0.02) 相比显著较低 (p < 0.001).
- 血管性母亲使用普雷尼松与胎儿TTR显著降低有关 (p = 0.001).
- 截止值为0.33的TTR显示了100%的灵敏度和92%的特异性,用于预测不良围产期结果.
结论:
- 患有血管炎的孕妇表现出较小的胎儿胸腺大小,由减少的TTR表示.
- 降低胎儿TTR可以作为不良围产期结果的潜在指标.
- 胎儿TTR与其他风险因素一起,可以帮助临床医生预测孕妇血管炎影响的怀孕中不良产周结果.
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