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在poly (rA) 中,通过非经典的间隔,通过quinacrine进行自我结构诱导的新见解:光谱和理论视角

Himal Das¹, Lopa Paul¹, Susmita Chowdhury¹

¹Biophysical Chemistry Laboratory, Physical Chemistry Section, Department of Chemistry, Jadavpur University, Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032, India.

International journal of biological macromolecules

|August 16, 2023

概括

在polyriboadenylic acid [poly (rA) ]中诱导自身结构会停止瘤细胞蛋白质的产生. 基纳克林非经典地合到多 (rA) 结构中,由范德瓦尔斯和H结合相互作用驱动.

科学领域:

生物化学生化学
分子生物学分子生物学
生物物理学的生物物理.

背景情况:

单链聚乙烯酸[poly (rA) ]的自我结构诱导抑制了瘤细胞中的蛋白质产生.
了解聚 (rA) 自建的分子机制对于开发新型癌症疗法至关重要.

研究的目的:

为了研究与quinacrine复杂化后在多 (rA) 中的自我结构诱导过程.
为了阐明 quinacrine-poly (rA) 相互作用的结合模式和热力学参数.
在复合体中探索 quinacrine 的光物理性质.

主要方法:

稳态和时间分辨率的光谱技术.
光学化分析. 光学化分析.
紫外线吸收光谱学. 紫外线吸收光谱学.
离子强度依赖的结合研究.
时间依赖密度函数理论 (TDDFT) 的计算.

主要成果:

光学化证实了在聚 (rA) 中在 quinacrine 复合后的自我结构组件的形成.
紫外线-Vis光谱学表明,基纳克林与聚 (rA) 具有合作性结合,其中介质模式涉及大约两个基对.
实验证据支持在自我结构的多 (rA) 复合体内对奎纳克林进行非传统的间歇.
复合表现出负和正变化,由范德瓦尔斯和键驱动.
离子强度研究显示,非多聚电解力是主导的.

结论:

基纳克林通过非常规的间隙与聚 (rA) 结合,形成自我结构的组件.
相互作用在热力学上是有利的,由特定的分子间力量驱动.
这些发现提供了关于聚 (rA) 自结构诱导及其由小分子调制的分子基础的见解.

关键词:

聚 (rA) 和基纳克林.自我结构的诱导感应.时间依赖密度函数理论

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