适应性营养干预稳定了血液透析患者的血清水平:使用真实世界的数据进行多中心分散的临床试验
Moon Kyung Chung1, Do Hyoung Kim2, Ji In Park3
1Interdisciplinary Program of Medical Informatics, Seoul National University College of Medicine, Seoul, Republic of Korea.
概括
适应性饮食干预改善了血液透析患者的控制和营养状况. 教育干预措施需要进一步开发,以获得类似的好处.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 临床营养学 临床营养学
- 公共卫生 公共卫生
背景情况:
- 接受血液透析 (HD) 的患者经常面临营养状况和电解质平衡方面的挑战.
- 现实世界的数据和适应性干预对于改善常规护理环境中的患者结果至关重要.
研究的目的:
- 评估适应性营养和教育干预对血液透析患者的影响.
- 用现实世界电子健康记录数据评估血清电解质和营养不良炎症评分 (MIS) 的变化.
主要方法:
- 一个分散的临床试验,涉及7个设施的153名血液透析患者,持续了8周.
- 患者被分配到控制,教育,饮食或联合干预组.
- 干预措施包括数字交付的教育和家庭交付的量身定制餐;分析了血清电解质和MIS.
主要成果:
- 进食干预显著稳定了血清水平 (β = -0.81 mg/dL),并增加了实现目标值的可能性 (OR = 1.21).
- 与教育组 (MIS = 5.10) 相比,饮食组显示营养状况有所改善 (MIS = 3.65).
- 血清,抑郁或自我有效性没有显著变化.
结论:
- 适应性饮食干预措施在现实环境中改善血液透析患者的控制和营养状况.
- 这些干预措施并没有对抑郁或自我效能产生负面影响.
- 需要进一步的研究来优化对血液透析患者的教育组成部分.
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