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用于骨组织工程的3D聚合物支架上的改性-氧酸盐-酸盐混合复合材料接口涂层

Deepak Poddar^1,2, Ankita Singh¹, Pranshu Rao³

¹Department of Chemistry, Netaji Subhas University of Technology, Dwarka Sector 3, New Delhi, 110078, India.

Macromolecular bioscience

|August 16, 2023

概括

这项研究开发了一种新型的3D支架,使用涂有阿伦德罗酸盐修饰酸 (MALD) 和酸的聚烯酸 (PCL). 增强的支架促进骨细胞的生长和分化,克服了传统支架和双酸盐药物输送的局限性.

科学领域:

生物材料工程生物材料工程
组织工程是组织工程.
药物输送系统药物输送系统

背景情况:

传统的3D支架有较低的孔隙性,机械强度较差,细胞与生物活性药物相互作用有限.
双酸盐刺激骨质生成,但在施用,生物可用性和部位特异性方面面临挑战.
开发先进的支架对于有效的骨再生和治疗治疗至关重要.

研究的目的:

为了设计一种新的3D脚手架,增强了细胞与生物活性药物接触,并改善了骨质生成潜力.
克服传统的支架和双酸药物输送方法的局限性.
创造一个生物模拟环境,刺激细胞增殖和分化,以修复骨.

主要方法:

在基托基质中制造3D聚烯酸 (PCL) 支架,涂上阿伦德罗酸改性酸 (MALD).
使用X射线光电子光谱 (XPS) 和扫描电子显微镜 (SEM) 进行脚手架结构和组成的表征.
在体外评估细胞粘附,增殖,骨质分化和发育的支架的机械强度.

主要成果:

该MALD复合体显示了阿伦德罗酸盐 (ALD) 的受控释放,释放率为86.28 ± 0.22%.
XPS和SEM证实了基托桑在脚手架接口上的颗粒沉积成功.
支架在一周内显著增强了细胞粘附,增殖和骨细胞分化,机械强度为3.03±0.2kPa,没有体外毒性.

结论:

这种新的MALD涂层PCL支架有效地模仿了原生细胞环境,促进了增强的细胞物质相互作用.
这种支架架构促进了细胞直接进入生物活性表面,改善了骨质生成.
开发的支架为骨组织工程和局部双酸盐输送提供了一个有前途的平台,解决了当前治疗方法的关键局限性.

关键词:

阿伦德罗纳特装饰的氧酸盐骨组织工程应用骨组织工程应用接口涂层是一种接口涂层.波罗根涂层转移漏漏漏有孔的脚手架是多孔的脚手架

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