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Updated: Jul 19, 2025

Tracking Bispecific Antibody-Induced T Cell Trafficking Using Luciferase-Transduced Human T Cells
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CLN-978是一种新型的半衰期延长的CD19/CD3/HSA特异性T细胞参与抗体结构,具有针对CD19低表达的B细胞恶性瘤的强效活性

Kristan Meetze1, Naveen K Mehta2, Bochong Li2

  • 1Cullinan Oncology Inc, Cambridge, Massachusetts, USA kmeetze@cullinanoncology.com.

Journal for immunotherapy of cancer
|August 16, 2023
PubMed
概括

一种新的双特异性抗体,CLN-978,有效地向低CD19表达B细胞恶性瘤. 这种疗法在临床前模型中显示出显著的抗瘤活性和耐受性,需要进一步的临床研究.

关键词:
CD4阳性T淋巴细胞CD8阳性的T淋巴细胞.细胞毒性,免疫学药物评估,临床前临床的T-淋巴细胞.

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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