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关节镜旋转手套修复后的生物调节愈合:随机概念证明试验 (BIOHACK) 的协议
Laurens Jan Houterman Allaart1,2,3, James Lech4,5, Arno Alexander Macken6,7
1Division of Orthopaedics and Trauma Surgery, Clinique Générale Annecy, Annecy, France laurensallaart@gmail.com.
BMJ open
|August 16, 2023
概括
这项研究调查了结合冷生物调制,光生物调制和电生物调制 (生物调制) 是否可以增强旋转手套修复愈合. 结果将决定这种非药物治疗方法在肌愈合方面的有效性.
科学领域:
- 整形外科手术 整形外科手术
- 再生医学是一种再生医学.
- 生物材料是一种生物材料.
背景情况:
- 对生物刺激 (生物增强) 进行旋转手套修复的兴趣正在增长.
- 目前的生物制剂在成分和患者选择方面缺乏共识,而且成本昂贵.
- 目前正在探索用于生物刺激的非药理策略.
研究的目的:
- 评估冷生物调制,光生物调制和电生物调制 (生物调制) 在旋转手套修复后对骨愈合的累积效应.
- 评估一种非药理学方法来增强旋转手套的愈合.
主要方法:
- 一项随机对照试验涉及146名患有全厚旋转手套撕裂的患者.
- 患者被分配到对照组或额外的生物调制方案组 (6周内7种自我适用的疗法).
- 主要结局:手术1年后通过MRI的Sugaya分类来评估旋转手套的愈合.
主要成果:
- N/A - 目前还没有研究结果.
结论:
- 没有-研究结论等待结果.
相关概念视频
Mismatch Repair
Overview
Gene Conversion
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
Mismatch Repair
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
