毛囊性淋巴瘤之后的古典霍奇金淋巴瘤:一个病例报告
1Department of Pathology, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
Journal of Yeungnam medical science
|August 16, 2023
概括
毛囊淋巴瘤 (FL) 和古典霍奇金淋巴瘤 (HL) 很少一起发生. 当FL治疗后出现大细胞淋巴瘤时,考虑经典HL并进行彻底的病理调查.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 毛囊性淋巴瘤 (FL) 和古典霍奇金淋巴瘤 (HL) 是B细胞瘤,它们很少同时发生.
- 区分这些淋巴瘤,特别是当FL治疗后存在大细胞形态时,会带来诊断挑战.
研究的目的:
- 以呈现一种古典HL的病例,该病例是在FL用rituximab-bendamustine治疗后出现的.
- 审查并将此案与有关顺序FL和HL的现有文献进行比较.
- 强调FL后大细胞淋巴瘤的关键病理诊断考虑因素.
主要方法:
- 一个55岁的女性患有IV期3A级FL,接受Rituximab-bendamustine治疗的病例报告.
- 通过淋巴结和肝脏活检,通过诊断确认经典HL.
- 文学综述和对连续FL和HL病例的比较分析.
主要成果:
- 一名患有FL的55岁妇女在完成修复药-木素化疗后的23个月内发展出经典HL.
- 这项研究在顺序FL和HL中发现了共享的基因变异 (例如,Bcl-2,Bcl-6转位),表明了共同的克隆起源.
- 经典HL是FL治疗后出现的大细胞淋巴瘤的关键差异诊断.
结论:
- 序列或复合FL和HL可以来自同一个克隆.
- 当大细胞淋巴瘤在FL治疗后被确定时,必须考虑经典HL.
- 组织学,免疫组织化学和分子研究对于准确的诊断至关重要.
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