声动力学细胞因子纳米复合物具有针对效应T细胞的特定刺激,用于联合癌症免疫疗法
Mengke Xu1, Jie Yu1, Chi Zhang1
1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore.
Angewandte Chemie (International ed. in English)
|August 16, 2023
概括
这项研究引入了一种用于癌症治疗的新型纳米免疫复合体,可以选择性地激活免疫细胞. 这种方法增强了抗瘤免疫疗法,通过向效应性T细胞和减少瘤微环境中的调节性T细胞.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米技术 纳米技术
背景情况:
- 细胞因子疗法通过调节瘤微环境 (TME) 中的免疫细胞相互作用,在癌症治疗中表现有前途.
- 细胞因子治疗的临床限制包括剂量依赖的副作用和非选择性免疫细胞刺激.
- 开发向免疫疗法对于有效的癌症治疗至关重要.
研究的目的:
- 开发用于向抗瘤免疫治疗的声动态细胞因子纳米免疫复合体 (SPNAI).
- 在TME中选择性地激活效应T细胞 (Teffs),同时抑制调节T细胞 (Tregs).
- 将声动力学疗法与免疫疗法结合起来,以加强癌症治疗.
主要方法:
- 与半导体聚合物纳米颗粒结合的抗素-2 (抗IL-2) 抗体 (S4B6),产生SPNA.
- 通过将SPNA与IL-2结合,形成SPNAI,从而可以选择性地阻断IL-2/Treg相互作用.
- 对SPNAI进行声波辐射,以产生单片氧 (1O2) 用于癌细胞死亡和免疫细胞激活.
主要成果:
- 在TME中,SPNAI可以选择性地激活Teffs,并抑制Tregs.
- 对SPNAI的声辐射诱导癌细胞中的免疫细胞死亡.
- 组合疗法促进树突细胞成熟和Teff增殖,增加Teffs/Tregs比率.
- SPNAI治疗抑制了瘤生长,抑制了肺转移,并预防了瘤复发.
结论:
- SPNAI代表了一种用于癌症治疗的新型声动力免疫疗法剂.
- 由SPNAI对Teffs的有针对性的激活和Tregs的抑制可以增强抗瘤免疫反应.
- 这种结合方法为管理初级瘤,转移和复发提供了一个有希望的策略.
相关概念视频
Tumor Immunotherapy
557
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
557
Cytotoxic T Cells-mediated Immune Response
971
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
971
Cancer Vaccines
403
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
403
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K


