在日本普通老年人群中,具有轻度认知障碍的结构性海马内部网络发生变化
Sera Kasai1, Keita Watanabe2, Yoshihito Umemura1
1Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Scientific reports
|August 16, 2023
概括
经过磁共振成像 (MRI) 分析的改变的海马内部网络,可以预测轻度认知障碍 (MCI),而不依赖于海马体积,这表明MCI中存在独特的病理.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 改变的海马网络与痴呆症有关.
- 用MRI评估海马内部网络是一项挑战.
- 轻度认知障碍 (MCI) 可能涉及明显的海马网络变化.
研究的目的:
- 用MRI研究海马内网络的结构共变性.
- 在患有MCI的患者中评估海马内网络的改变.
- 为了确定与MCI相关的网络变化是否独立于海马体积.
主要方法:
- 在2122名参与者 (218名MCI,1904名认知正常的老年人) 的横截面研究.
- 使用3T MRI与3D T1加权成像.
- 采用独立组件分析 (ICA) 来提取海马结构协差网络.
主要成果:
- 国际海事局确定了16个海马内网络 (2个双边,14个双边).
- 两个网络 (一个双边,一个双边) 显著预测了MCI.
- 这些预测网络的改变独立于海马体积和其他共变量.
结论:
- 改变的海马内部网络是MCI的显著预测因素.
- 海马网络和MCI之间的关系独立于海马缩.
- 这些发现表明,在MCI中,除了大脑体积损失之外,还有不同的病理机制.
更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
15.0K
09:44Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method
Published on: June 22, 2017
15.1K
相关概念视频
Role of Hippocampus in Memory
315
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
315
Cognitive Development During Adulthood
157
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
157
