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对相分离蛋白SMNDC1的药理性干扰

Lennart Enders1, Marton Siklos1, Jan Borggräfe2,3

  • 1CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090, Vienna, Austria.

Nature communications
|August 16, 2023
PubMed
概括

针对SMNDC1Tudor域的小分子抑制剂改变了其局部和蛋白质相互作用,影响了基因拼接. 这些发现为研究核凝聚物和细胞身份提供了新的途径.

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Separation of Sister Chromatids02:17

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At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
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