胺对冲动反射和其休息状态大脑的情感调节的影响是相关的
Zümrüt Duygu Sen1,2,3,4, Tara Chand1,2,5,6, Lena Vera Danyeli1,2,3
1Department of Psychiatry and Psychotherapy, Jena University Hospital, Philosophenweg 3, 07743, Jena, Germany.
Scientific reports
|August 16, 2023
概括
胺并没有增强对不愉快刺激的惊反应,但在健康的男性中减少了对愉快刺激的惊反射减弱. 这表明胺可以降低积极经历的激励影响.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 神经成像是一种神经成像.
背景情况:
- 胺是一种快速起作用的抗抑郁药,已知对神经反应有影响.
- 胺对行为情感反应性的影响仍然不清楚.
- 影响调节的惊反射范式 (AMSR) 测量了价值特异性的行为反应.
研究的目的:
- 通过AMSR研究胺对行为情感反应的作用.
- 为了检查胺对桃体-突通路中的静止状态功能连接 (rsFC) 的影响.
- 测试凯胺改变惊反射调制并削弱rsFC的假设.
主要方法:
- 这是一项随机,双盲,安慰剂控制的交叉研究,涉及32名健康男性参与者.
- 超高场静止状态功能磁共振成像 (7T) 在安慰剂/S-胺注入前后.
- 在基线和输液后24小时给药的AMSR任务.
主要成果:
- 胺没有影响惊对不愉快刺激的强化.
- 氨酸显著减少了对愉快刺激的震惊减弱,与药物水平相关.
- 氨酸降低了杏仁体-突突突起反射通路内的rsFC.
结论:
- 胺对健康个体的行为情感反应的主要影响是对愉快刺激的反应减弱.
- 这表明胺可能会降低积极刺激的动机突出性.
- 这些发现突出了胺除了抗抑郁作用之外的复杂效应.
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