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Updated: Jul 19, 2025

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在Mycobacterium tuberculosis中对whiB7的分析揭示了新的AT删除突变

Olabisi Flora Davies-Bolorunduro1,2,3, Bharkbhoom Jaemsai2, Wuthiwat Ruangchai1

  • 1Pornchai Matangkasombut Center for Microbial Genomics, Department of Microbiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, 10400, Thailand.

Scientific reports
|August 16, 2023
PubMed
概括

对超过4万个Mycobacterium结核病分离物的基因组分析揭示了 whiB7基因中的关键突变. 这些发现揭示了抗生素耐药性的机制,并为新的结核病治疗提供了见解.

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Mutations in Microorganisms01:18

Mutations in Microorganisms

Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
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