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Updated: Jul 19, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

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全基因组解揭示了阿尔茨海默氏症的弹性表观遗传特征

Eloise Berson1,2,3, Anjali Sreenivas4,5, Thanaphong Phongpreecha4,5,6

  • 1Department of Pathology, Stanford University, Stanford, CA, USA. eloiseb@stanford.edu.

Nature communications
|August 16, 2023
PubMed
概括

一种新的深度学习方法Cellformer通过测序 (ATAC-seq) 数据来解构大量的转化酶可访问染色质的测试. 这种方法揭示了细胞类型特定的基因调节和阿尔茨海默氏病性背后的表观遗传机制.

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