在自闭症中,内在功能组织的分歧不对称
Bin Wan1,2,3,4, Seok-Jun Hong5, Richard A I Bethlehem6
1Otto Hahn Research Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. binwan@cbs.mpg.de.
Molecular psychiatry
|August 16, 2023
概括
患有自闭症的个体表现出大脑功能不对称的改变,特别是在语言网络中. 功能横向化的这些差异可能源于不典型的发育轨迹,与自闭症特征严重程度相关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 认知科学 认知科学
背景情况:
- 自闭症谱系障碍 (ASD) 是一种神经发育状况,其特点是社会认知和语言缺陷,以及非典型的感觉感知功能.
- 之前的研究表明,与神经类型个体相比,自闭症患者的大脑结构不对称性和功能激活横向性降低的微妙变化.
- 在自闭症中,大脑连接体内的功能不对称的内在组织仍然不完全理解.
研究的目的:
- 研究自闭症内在功能梯度的半球间和半球内不对称性.
- 为了检查脑连接体组织沿着关键功能轴的系统级半球失衡.
- 探索功能不对称,发育轨迹和自闭症特征严重程度之间的关系.
主要方法:
- 分析内在的功能梯度,捕捉连接体组织在三个轴:感官默认,体运动视觉和默认多重需求网络.
- 在自闭症和神经类型个体 (NAI) 之间的功能梯度中对半球不对称的比较.
- 评估语言网络不对称性的年龄相关变化以及自闭症特征严重性的内半球和内半球特征的预测价值.
主要成果:
- 与NAI相比,自闭症患者在语言网络组织方面表现出左向功能不对称性减少.
- 与NAI不同,自闭症患者的语言网络不对称性在不同年龄组之间没有显著差异.
- 半球内部,但不是半球间,功能特征预测了自闭症特征的严重程度.
结论:
- 功能横向化,无论是区域性的还是模式化的,在自闭症中,在系统层面上发生了改变.
- 功能组织不对称的非典型发育轨迹可能是自闭症中观察到的半球失衡的基础.
- 改变的功能不对称性,特别是在语言网络内,与自闭症的神经发育特征和特征严重程度有关.
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