活体供体肝移植治疗儿科急性肝衰竭:挑战和结果
Viniyendra Pamecha1, Nilesh Sadashiv Patil2, Sanyam Falari2
1Department of Liver Transplant and Hepato-Pancreato-Biliary Surgery, Institute of Liver and Biliary Sciences, D-1, Acharya Shree Tulsi Marg, Vasant Kunj, New Delhi, 110070, India. viniyendra@gmail.com.
Hepatology international
|August 16, 2023
概括
针对儿科急性肝衰竭 (PALF) 的活体供体肝移植 (LDLT) 提供了一个具有良好的长期存活率的拯救生命的选择. 早期转诊和选择对于改善这些重症儿童的治疗结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 儿科胃肠病学 儿科胃肠病学
- 移植手术 移植手术
背景情况:
- 儿科急性肝衰竭 (PALF) 在管理和治疗方面存在重大挑战.
- 肝移植 (LT) 是PALF的一个关键干预,活体供体肝移植 (LDLT) 起着至关重要的作用.
研究的目的:
- 研究患有急性肝衰竭的儿科患者的LDLT相关的挑战和结果.
- 为了评估PALF的LDLT的疗效和生存率.
主要方法:
- 在11年内对315名PALF患者进行了回顾性分析.
- 专注于接受LT的42名患者 (41名LDLT,1名DLT),将结果与没有接受LT的患者进行比较.
- 对影响生存的移植前和移植后因素的分析.
主要成果:
- 41名患有PALF的儿童接受了LDLT,符合国王学院的标准,分别为75.6%和70.9%的1年和5年的患者和移植生存率.
- 没有接受LT治疗的患者的生存率明显较低 (24%).
- 像LT前的败血症和脑等因素与LT后的死亡率有关,而血酶改善了神经恢复.
结论:
- LDLT是PALF的救生手术,可以及时移植.
- 尽管晚期呈现,良好的长期存活是可以实现的LDLT.
- 强调早期转诊和优化患者选择对于PALF中成功的LDLT的重要性.
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