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在新辅助疗法后的免疫微环境与胰腺癌患者的前期手术相比

Eline S Zwart^1,2,3, Thomas van Ee^2,3,4, Deesje Doppenberg^1,5

¹Department of Surgery, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Journal of cancer research and clinical oncology

|August 16, 2023

概括

在胰腺癌患者中,新辅助的FOLFIRINOX治疗促进了亲炎性免疫反应,与凝胺加放射治疗或前期手术不同. 瘤组织通常会在治疗后表现出一种更具免疫抑制性的微环境.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
手术瘤学手术瘤学

背景情况:

胰腺管腺癌 (PDAC) 治疗越来越多地涉及手术前的新辅助疗法.
新辅助疗法对PDAC免疫微环境的影响尚不清楚.
这项研究调查了新辅助治疗后PDAC瘤中的免疫细胞概况与前期手术.

研究的目的:

分析和比较胰腺癌的免疫微环境.
为了评估新辅助剂FOLFIRINOX和凝胺加放射治疗 (gem-RT) 对免疫细胞的影响.
为了将这些效应与接受前置手术的患者的瘤进行比较.

主要方法:

切除的PDAC瘤组织的多谱成像.
分析了接受前期手术 (n=10),新辅助性FOLFIRINOX (n=10) 或新辅助性gem-RT (n=9) 的患者的样本.
病理学家从中部和侵入性前部瘤区域选择的样本,通过Vectra Polaris进行分析.

主要成果:

与gem-RT或前期手术相比,新辅助药FOLFIRINOX带来了更有利于炎症的特征 (更少的调节T细胞,更多的CD8T细胞).
福利诺克斯还降低了CD163+巨细胞,并增加了CD163-到CD163+的比率.
Gem-RT显示出更强的免疫抑制特征,CD8 T细胞较少,CD163+巨细胞与CD8的比例较高.

结论:

新辅助剂FOLFIRINOX在PDAC瘤中诱导了一种促炎性免疫反应.
新辅助的gem-RT和前置手术都与更具免疫抑制性的瘤微环境有关.
在所有治疗组中,瘤组织始终表现出比邻近的非瘤组织更强的免疫抑制环境.

关键词:

免疫系统的免疫系统.新辅助疗法是一种新辅助疗法.胰腺癌是一种胰腺癌.手术手术手术瘤微环境是一个微环境.

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