中线 thalamus 的 xiphoid 核控制冷诱导寻找食物的过程
Neeraj K Lal1, Phuong Le2, Samarth Aggarwal1
1Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA.
Nature
|August 16, 2023
概括
在寒冷的情况下,哺乳动物增加了寻找食物的速度,主要是由于能量消耗,而不是感觉寒冷. 大脑中的状核 (Xi) 控制着这种由寒冷引起的食行为.
科学领域:
- 神经科学是一个神经科学.
- 动物行为 动物行为
- 代谢调节 代谢调节 代谢调节 代谢调节
背景情况:
- 内热动物花费大量的能量来维持体温.
- 哺乳动物在寒冷的环境中增加食物摄入量,以抵消能源成本.
- 寒冷诱导养的神经基础仍然不太清楚.
研究的目的:
- 阐明神经机制,将寒冷暴露,能源消耗和哺乳动物寻找食物的行为联系起来.
- 确定特定的大脑区域参与调节对寒冷的食反应.
主要方法:
- 在小鼠的行为和代谢分析.
- 全脑c-Fos映射以识别激活的神经区域.
- 在体内成像,以监测神经活动.
- 神经回路的光遗传和化学遗传操纵. 神经回路的光遗传和化学遗传操纵.
- 病毒追踪用于绘制神经预测的地图.
主要成果:
- 鼠标在节能和在寒冷中寻找食物之间表现出动态的切换,由能源支出驱动.
- 体 (Xi) 中的体核通过长时间暴露在高能耗的寒冷中被选择性地激活.
- 西神经元活动与在寒冷中寻找食物的情节相关.
- 刺激Xi神经元促进冷诱导的食,而抑制抑制它.
- 一个Xi-to-nucleus accumbens投射介导了这些养行为.
结论:
- 体 (Xi) 核是一个关键的大脑区域,控制寒冷诱导的食.
- 习神经元编码了一个取决于环境的价值开关,促进在寒冷中寻找食物.
- 这种机制对于在寒冷条件下维持内热动物的能量恒温至关重要.
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