新辅助化疗免疫疗法增加了瘤免疫淋巴细胞透到可切除的非小细胞肺癌中
Tianxiang Chen1, Zhengqi Cao1, Yingjia Sun1
1Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
Annals of surgical oncology
|August 16, 2023
概括
对非小细胞肺癌的新辅助化疗免疫疗法增加了瘤免疫淋巴细胞. 治疗前的免疫细胞透预测了治疗反应,有助于患者选择更好的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 翻译研究是翻译研究.
背景情况:
- 新辅助化疗免疫疗法 (NCIT) 在非小细胞肺癌 (NSCLC) 方面显示出前景.
- NCIT疗效的潜在机制在很大程度上是未知的.
- 了解这些机制对于优化治疗策略至关重要.
研究的目的:
- 在NSCLC患者的NCIT后,研究瘤免疫微环境的变化.
- 为了确定预测NCIT反应的潜在生物标志物.
- 为了将免疫细胞透与病理反应相关联.
主要方法:
- 对32名IIA-IIIC期NSCLC患者进行了回顾性分析,这些患者接受了NCIT和手术.
- 在处理前和后的样本上进行多重免疫光 (mIF) 染色和RNA分析.
- 免疫细胞群在响应者和非响应者之间进行比较.
主要成果:
- NCIT导致瘤透性淋巴细胞 (TILs) 在肌层 (stroma) 的增加,但不是瘤区域.
- 在NCIT后,CD8+ T细胞和三级淋巴体结构在两个响应组都增加.
- 在NCIT前的CD3,FOXP3+和CD8+/PD-1+细胞水平使响应者与不响应者区分开来.
结论:
- 治疗前免疫细胞透与病理完整反应有关.
- 在NCIT后增加TIL是治疗疗效的有希望的指标.
- 确定基线免疫特征可以指导患者选择NCIT.
更多相关视频
07:45Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis
Published on: January 26, 2024
2.0K
10:29Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
10.6K
相关概念视频
01:27Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K