病毒性疾病管理中的代谢学导向纳米技术:COVID-19是一个案例研究
Marwa O El-Derany1, Diana M F Hanna2, John Youshia3
1Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Pharmacological reports : PR
|August 16, 2023
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 改变了宿主代谢以复制. 这篇评论探讨了COVID-19和纳米颗粒如何影响脂质,氨基酸和碳水化合物代谢,为新疗法提供了见解.
科学领域:
- 代谢学 代谢学 代谢学
- 病毒学 病毒学
- 纳米技术纳米技术
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致COVID-19,影响呼吸和代谢系统.
- 纳米粒子对于mRNA疫苗至关重要,但可以改变宿主代谢.
- 了解代谢变化对于对抗病毒感染和评估基于纳米的干预措施至关重要.
研究的目的:
- 审查和分析COVID-19和纳米颗粒对宿主代谢的影响.
- 为了研究脂质,氨基酸和碳水化合物通路的变化.
- 为了将新陈代谢变化与免疫和病毒复制相关联.
主要方法:
- 在PubMed,ScienceDirect和科学网上进行文献搜索.
- 对代谢学,免疫力,SARS-CoV-2感染和纳米粒子效应研究的分析.
- 汇编有关代谢物水平变化的数据.
主要成果:
- SARS-CoV-2 破坏宿主代谢途径以支持病毒复制.
- 纳米粒子,包括那些没有药物的纳米粒子,可以影响生物系统和代谢物水平.
- 代谢分析显示,病毒感染和宿主代谢状态之间存在显著的相互关系.
结论:
- 由SARS-CoV-2引起的代谢途径中断具有治疗目标.
- 纳米粒子诱导的代谢变化需要对疫苗和药物开发进行仔细考虑.
- 代谢学为了解宿主-病原体相互作用和纳米-生物相互作用提供了一个强大的镜头.
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