极低出生体重婴儿的体积向通风与压力控制通风:一个随机对照试验的协议
Jun Tang1, Lingyue Gong2, Tao Xiong2
1Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Renmin South Road #16, Wuhou District, Chengdu, China. tj1234753@sina.com.
Trials
|August 16, 2023
概括
针对体积的通风 (VTV) 可能会减少新生儿的死亡或支气管肺功能障碍 (BPD). 这项研究比较了VTV和压力控制通风 (PCV) 在非常低出生体重 (VLBW) 婴儿,以评估VTV对这个脆弱群体的好处.
科学领域:
- 新生儿重症监护服务新生儿重症监护服务
- 儿科呼吸系统医学 儿科呼吸系统医学
- 机械通风策略 机械通风策略
背景情况:
- 机械通风 (MV) 对重症新生儿,特别是早产婴儿至关重要.
- 长期或不适当的MV可以导致呼吸器相关的肺损伤.
- 以前的审查表明,体积向通风 (VTV) 减少了新生儿的死亡或支气管肺形 (BPD),但缺乏关于非常低出生体重 (VLBW) 亚组的数据.
研究的目的:
- 为了比较VTV与压力控制通风 (PCV) 在VLBW婴儿的疗效.
- 为优化VLBW婴儿的MV提供临床证据.
- 为了减少VLBW婴儿的死亡率和MV相关并发症.
主要方法:
- 一个单中心随机对照试验 (RCT) 与1:1分配给VTV或PCV组.
- 主要结局:死亡或BPD在36周的月经后年龄组合.
- 二次结局:BPD,死亡,MV的持续时间,氧气使用,住院,再灌输率和成本.
主要成果:
- 这个部分不在所提供的摘要中.
结论:
- 之前的一项系统性审查表明,VTV对新生儿有好处,但没有专门分析VLBW婴儿.
- 本RCT旨在提供关于VTV对VLBW患者的优势的重要证据.
- 该研究旨在为高风险人群中关于MV的临床实践提供信息.
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